Anticonvulsants for the Treatment of Alcohol Withdrawal Syndrome and Alcohol Use Disorders
Alpha2-adrenergic agonists like clonidine and dexmedetomidine should not be used alone to prevent alcohol withdrawal seizures or delirium as they “do not treat the underlying pathophysiology” (79). Paradoxically, length of stay in the meta-analysis favored standard benzodiazepine therapy when analyzing cohort studies, but dexmedetomidine adjunctive therapy was significantly favored when randomized controlled trials were analyzed. …